Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease

doi:10.4291/wjgp.v16.i4.111029

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Dec 22, 2025; 16(4): 111029
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111029

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Figure 3 Gut–liver–brain axis examining the association between metabolic dysfunction–associated steatotic liver disease and depression/anxiety. SCFA: Short-chain fatty acids; LPS: Lipopolysaccharides; BBB: Blood–brain barrier; BDNF: Brain-derived neurotrophic factor; GABA: Gamma-aminobutyric acid; MASLD: Metabolic dysfunction–associated steatotic liver disease.

Citation: Sampada, Naseem M, Solanki M, Sharma R, Singh C, Sohal A. Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease. World J Gastrointest Pathophysiol 2025; 16(4): 111029
URL: https://www.wjgnet.com/2150-5330/full/v16/i4/111029.htm
DOI: https://dx.doi.org/10.4291/wjgp.v16.i4.111029

Sampada, Naseem M, Solanki M, Sharma R, Singh C, Sohal A. Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease. World J Gastrointest Pathophysiol 2025; 16(4): 111029 [PMID: 41479860 DOI: 10.4291/wjgp.v16.i4.111029]

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