©The Author(s) 2025.
World J Gastrointest Pathophysiol. Sep 22, 2025; 16(3): 108952
Published online Sep 22, 2025. doi: 10.4291/wjgp.v16.i3.108952
Published online Sep 22, 2025. doi: 10.4291/wjgp.v16.i3.108952
Table 4 Gut-skin axis–linked diseases and their microbial dysbiosis profiles
| Condition | Gut microbiome changes | Skin microbiome changes |
| Atopic dermatitis | ↓Bifidobacteria, ↓F. prausnitzii, ↑Enterobacteriaceae | ↑S. aureus, ↓microbial diversity |
| Psoriasis | ↑Ruminococcus, ↓Akkermansia muciniphila, ↓Faecalibacterium prausnitzii | ↑Corynebacterium, ↑Streptococcus |
| Rosacea | ↑Prevotella intermedia, ↓Cutibacterium | ↑Demodex folliculorum, ↑Gordonia |
| Hidradenitis suppurativa | ↑Porphyromonas, ↑Prevotella, ↓diversity | ↑anaerobes in lesions, ↓alpha diversity |
| Celiac disease | ↑Proteobacteria, ↓Lactobacillus, ↑Candida | Associated with dermatitis herpetiformis |
| Seborrheic dermatitis | Altered lipid metabolism-related bacteria (e.g., ↑Enterobacteriaceae) | ↑Malassezia species (esp. M. restricta), altered yeast load |
| Acne vulgaris | ↓Lactobacillus, ↑Proteobacteria, ↓diversity | ↑Cutibacterium acnes (formerly Propionibacterium acnes) |
- Citation: Singla N, Singla K, Attauabi M, Aggarwal D. Gut-skin axis: Emerging insights for gastroenterologists-a narrative review. World J Gastrointest Pathophysiol 2025; 16(3): 108952
- URL: https://www.wjgnet.com/2150-5330/full/v16/i3/108952.htm
- DOI: https://dx.doi.org/10.4291/wjgp.v16.i3.108952