Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations

doi:10.4291/wjgp.v16.i3.107954

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 3

This Article

(53)

(43)

(0)

(841)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Pathophysiology

ISSN

2150-5330

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastrointest Pathophysiol. Sep 22, 2025; 16(3): 107954
Published online Sep 22, 2025. doi: 10.4291/wjgp.v16.i3.107954

Table 3 Kirsten rat sarcoma viral oncogene homolog, neuroblastoma RAS viral oncogene homolog, and v-raf murine sarcoma viral oncogene homolog B1 mutations by pathological stage in patients with colorectal cancer patients (n = 799), n (%)

Protein change	Nucleotide change	Overall	pT1	pT2	pT3	pT4	Unknown
Protein change	Nucleotide change	Overall	65 (8.1)	102 (12.8)	344 (43.1)	257 (32.2)	31 (3.8)
NM_004985.5 (KRAS) hot-spot mutations
KRAS wildtype	N/A	483 (60.5)	43 (8.8)	57 (11.8)	228 (47.1)	133 (27.5)	23 (4.8)
KRAS codon 12
p.Gly12Asp (G12D)	c.35G>A	108 (13.5)	6 (5.6)	17 (15.7)	46 (42.6)	35 (32.4)	4 (3.7)
p.Gly12Val (G12V)	c.35G>T	72 (9.0)	5 (6.9)	8 (11.1)	25 (34.7)	33 (45.8)	1 (1.5)
p.Gly12Cys (G12C)	c.34G>T	25 (3.1)	2 (8.0)	4 (16.0)	10 (40.0)	9 (36.0)	0 (0.0)
p.Gly12Ser (G12S)	c.34G>A	18 (2.3)	3 (16.7)	3 (16.7)	7 (38.8)	5 (27.8)	0 (0.0)
p.Gly12Ala (G12A)	c.35G>C	8 (1.0)	1 (12.5)	1 (12.5)	2 (25.0)	3 (37.5)	1 (12.5)
p.Gly12Arg (G12R)	c.34G>C	5 (0.6)	0 (0.0)	2 (40.0)	0 (0.0)	4 (60.0)	0 (0.0)
KRAS codon 13
p.Gly13Asp (G13D)	c.38G>A	62 (7.7)	4 (6.4)	8 (12.8)	20 (32.3)	30 (48.5)	0 (0.0)
KRAS codon 61
p.Gln61His (Q61H)	c.183A>T	5 (0.6)	1 (20.0)	1 (20.0)	1 (20.0)	2 (40.0)	0 (0.0)
p.Gln61His (Q61H)	c.183A>C	6 (0.7)	1 (16.7)	0 (0.0)	1 (16.7)	3 (50.0)	1 (16.7)
p.Gln61Leu (Q61L)	c.182A>T	4 (0.5)	0 (0.0)	0 (0.0)	3 (75.0)	0 (0.0)	1 (25.0)
p.Gln61Arg (Q61R)	c.182A>G	3 (0.4)	0 (0.0)	1 (33.3)	1 (33.3)	1 (33.3)	0 (0.0)
p.Gln61Glu (Q61E)	c.181C>G	1 (0.1)	0 (0.0)	0 (0.0)	1 (100)	0 (0.0)	0 (0.0)
NM_002524.5 (NRAS) hot-spot mutations
NRAS wildtype	N/A	738 (92.3)	61 (8.3)	97 (13.2)	317 (42.8)	235 (31.8)	29 (3.9)
NRAS codon 12
p.Gly12Asp (G12D)	c.35G>A	6 (0.8)	0 (0.0)	0 (0.0)	3 (50.0)	2 (33.3)	1 (26.7)
p.Gly12Val (G12V)	c.35G>T	3 (0.4)	0 (0.0)	0 (0.0)	1 (33.3)	2 (66.7)	0 (0.0)
p.Gly12Cys (G12C)	c.34G>T	1 (0.1)	0 (0.0)	0 (0.0)	0 (0.0)	1 (100)	0 (0.0)
p.Gly12Ser (G12S)	c.34G>A	1 (0.1)	0 (0.0)	0 (0.0)	1 (100)	0 (0.0)	0 (0.0)
NRAS codon 13
p.Gly13Val (G13V)	c.38G>T	2 (0.3)	0 (0.0)	0 (0.0)	0 (0.0)	2 (100)	0 (0.0)
NRAS codon 61
p.Gln61Lys (Q61K)	c.181C>A	12 (1.5)	0 (0.0)	2 (16.7)	7 (58.3)	3 (25.0)	0 (0.0)
p.Gln61Arg (Q61R)	c.182A>G	6 (0.8)	1 (16.7)	0 (0.0)	3 (50.0)	2 (33.3)	0 (0.0)
p.Gln61His (Q61H)	c.183A>T	2 (0.3)	0 (0.0)	1 (50.0)	1 (50.0)	0 (0.0)	0 (0.0)
p.Gln61Leu (Q61L)	c.182A>T	1 (0.1)	0 (0.0)	0 (0.0)	0 (0.0)	1 (100)	0 (0.0)
Unknown NRAS	N/A	27 (3.3)	3 (11.1)	2 (7.4)	12 (44.5)	9 (33.3)	1 (3.7)
NM_004333.6 (BRAF) V600 mutations
BRAF V600 wildtype	N/A	746 (93.4)	62 (8.3)	99 (13.3)	318 (42.6)	238 (31.9)	29 (3.9)
p.Val600Glu (V600E)	c.1799T>A	48 (6.0)	3 (6.3)	3 (6.3)	25 (52.2)	15 (31.1)	2 (4.1)
Unknown BRAF	N/A	5 (0.6)	0 (0.0)	0 (0.0)	0 (0.0)	1 (20.0)	4 (80.0)

BRAF: V-raf murine sarcoma viral oncogene homolog B1; KRAS: Kirsten rat sarcoma viral oncogene homolog; NRAS: Neuroblastoma RAS viral oncogene homolog; pT: Pathological stage; N/A: Not applicable.

Full Size Table

Citation: Abdelgadir O, Kuo YF, Khan MF, Okorodudu AO, Cheng YWO, Dong J. Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations. World J Gastrointest Pathophysiol 2025; 16(3): 107954
URL: https://www.wjgnet.com/2150-5330/full/v16/i3/107954.htm
DOI: https://dx.doi.org/10.4291/wjgp.v16.i3.107954

Abdelgadir O, Kuo YF, Khan MF, Okorodudu AO, Cheng YWO, Dong J. Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations. World J Gastrointest Pathophysiol 2025; 16(3): 107954 [PMID: 41024990 DOI: 10.4291/wjgp.v16.i3.107954]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.