Pancreatic neuroendocrine tumors: A case-based evidence review

Table 3 Tumor, node, metastasis and American Joint Committee on Cancer classifications for staging of pancreatic neuroendocrine tumors[27]

AJCC	TNM	Description
I	T1 N0 M0	Tumor < 2 cm, local to pancreas. No nodal disease/metastasis
II	T2 N0 M0	2 cm < Tumor < 4 cm, local to pancreas. No nodal disease/metastasis
	T3 N0 M0	Tumor > 4 cm, extended to duodenum/common bile duct. No nodal disease or metastasis
III	T1-3/4 N1 M0	Tumor extended to adjacent organs (stomach, spleen, colon/adrenals) or spread haematogenously (T4). It may present with lymph node spread (N1) but no distant metastasis
IV	Tx Nx M1	Any size (Tx), any nodal spread (Nx), but distant metastasis (M1)