P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis

Figure 1 Scoring of the disease activity index in the in the sham, 2,4,6-trinitrobenzene sulfonic acid and brilliant blue G groups. A: The disease activity index was calculated by summing the score parameters: Mild activity was classified from 1 to 4; moderate activity, from 5 to 8; and maximal activity from 9 to 12. The scores were categorized as follows according to the corresponding parameters; B: Weight change score: 0 ≤ 1, 1 = 1-5, 2 = 5-10, 3 = 10-15, and 4 ≥ 15%; C: Occult/gross rectal bleeding: 0 = normal, 1 = occult blood +, 2 = occult blood ++, 3 = occult blood +++, and 4 = gross bleeding; D: Stool consistency score: 0 = normal (well-formed pellets), 1 = normal, 2 = loose stool (pasty and semiformed stools that do not stick to the anus), 3 = loose stool, and 4 = diarrhea (liquid stools that stick to the anus). DAI: Disease activity index; TNBS: 2,4,6-trinitrobenzene sulfonic acid; BBG: Brilliant blue G.