Evaluation of DNA synthesis with carbon-11-labeled 4&prime;-thiothymidine

doi:10.4329/wjr.v8.i9.799

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World Journal of Radiology

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1949-8470

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Radiol. Sep 28, 2016; 8(9): 799-808
Published online Sep 28, 2016. doi: 10.4329/wjr.v8.i9.799

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Figure 2 Radiosynthesis of 4’-[methyl-¹¹C]-thiothymidine. The imaging agent ¹¹C-4DST was synthesized by methylation of 5-tributylstannyl-4'-thio-2'-deoxyuridine via a palladium-mediated Stille cross-coupling reaction with ¹¹C-methyl iodide. ¹¹C-4DST: 4’-[methyl-¹¹C]-thiothymidine; DMF: N,N-Dimethylformamide; P(o-tolyl)₃: Tri(o-tryl)phosphine; Pd₂(dba)₃: Tris(dibenzylideneacetone)dipalladium(0).

Citation: Toyohara J. Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine. World J Radiol 2016; 8(9): 799-808
URL: https://www.wjgnet.com/1949-8470/full/v8/i9/799.htm
DOI: https://dx.doi.org/10.4329/wjr.v8.i9.799