Comparisons between glucose analogue 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions

Figure 2 Evidence of the complementary features of 2-deoxy-2-(¹⁸F)fluoro-D-glucose and ¹⁸F-sodium positron emission tomography/computed tomography in the pelvis of the same breast cancer patient. An ¹⁸F-NaF avid sclerotic lesion was detected in the right sacrum in absence of significant ¹⁸F-FDG uptake. By contrast high uptake of ¹⁸F-FDG was present in a small lytic lesion in the left iliac bone. Due to the absence of a significant local bone reaction, this small lesion did not show any uptake of ¹⁸F-NaF. Both lesions corresponded to metastatic sites of disease and disappeared after chemotherapy. ¹⁸F-FDG: 2-deoxy-2-(¹⁸F)fluoro-D-glucose; ¹⁸F-NaF: ¹⁸F-sodium; PET/CT: Positron emission tomography/computed tomography.