Diffusion-weighted imaging of the liver: Current applications

Table 4 Histological differentiation of hepatocellular carcinoma using apparent diffusion coefficient

	Tesla	Respiratory	b-value (s/mm2)	Well-diff HCC(×10-3 mm2/s)	Mod diff HCC(×10-3 mm2/s)	Poorly diff HCC(×10-3 mm2/s)	Difference
Saito et al[113]	1.5	RT	100, 800	1.25 ± 0.25	1.12 ± 0.22	1.13 ± 0.23	NS
Nasu et al[114]	1.5	RT	0, 500	1.45 ± 0.35	1.46 ± 0.32	1.36 ± 0.29	NS
Heo et al[77]	1.5	FB	0, 1000	1.2 ± 0.22	1.1 ± 0.10	0.9 ± 0.13	p < w, m
Nakanishi et al[80]	1.5	RT	50, 1000	NA	1.29 ± 0.21	1.07 ± 0.15	p < m
Nishie et al[75]	1.5	RT	0, 500, 1000	1.21 ± 0.11	1.14 ± 0.26	0.76 ± 0.10	p < w, m
Guo et al[79]	3.0	BH	0, 600	1.43 ± 0.09	1.34 ± 0.19	1.16 ± 0.16	p < w, m

RT: Respiratory trigger; BH: Breath holding; FB: Free breathing; ADC: Apparent diffusion coefficient. p < w, m: ADC in poorly differentiated HCC was significantly lower than ADC in well-differentiated HCC and moderately differentiated HCC; p < m: ADC in poorly differentiated HCC was significantly lower than ADC in moderately differentiated HCC; NS: No significant difference in ADC was observed for each histological grade; NA: Not applicable.