From histology to micro-CT: Measuring and modeling resorption cavities and their relation to bone competence

Table 2 Change of eroded surface, erosion depth and wall thickness in common bone diseases (postmenopausal osteoporosis, male idiopathic osteoporosis, glucocorticoid induced osteoporosis) as reported in literature

Disease	Parameter	Change	Values1 1Significantly lower than control 2Significantly higher than control
PmOP	W.Th (μm)	↓	40.74a (31.6-54.3)1[56] 36.2 (6.4)1[21] 28.3 (20.1-34.8)1[53] 35.3 (2.0)1[32] 28.0 (4.44)1[57] 29.3 (1.4)[73] 31.2 (0.4)-32.1 (0.5)[64] 41.8 (4.25)-49.0 (8.93)[67]
	ES/BS (%)	b↓	5.3a (1.7-18.1)[56] 6.0 (3.0)[21] 4.8 (2.7)[57] 1.67 (0.48)[73] 4.9 (2.9)[71] 1.89 (0.12)-3.41 (0.5)[64] 4.49 (1.6) - 6.55 (1.62)[65] 2.18 (1.24)[61] 2.42 (Q 1.31-2.93)[72] 4.7 (Q 3.3-5.7)-5.2 (Q 3.2-6.9)[67]
	E.De (μm)	b	55a (37.3-82)[56] 48.5 (43.8-53.2)[8] 50.0 (13.4)[32] 22 (5)[71] 13.5 (0.43)-15.8 (0.91)[64]
	EV/BV (%)		0.46 (0.04)-1.21 (0.29)[64]
MIOP	ES/BS (%)	↑	9.7 (1.7)[55] 7.5 (1.3-17.7)[58]
	E.De (μm)	b	44.7 (9.3)[58]
	W.Th (μm)	b↓	35.3 (7.5)1[58]
GC induced OP	EV/BV (%)		0.44 (0.1)[60]
	ES/BS (%)	b↑	2.3 (0.4)[60] 4.06 (2.45)[61]
	E.De (μm)	↑	15.0 (1.3)[60]
	W.Th (μm)	↓	30.6 (0.8)[60]

Significant difference vs control indicated (¹Significantly lower than control;

²Significantly higher than control);

^aMedian; Values presented as mean ± SD, mean (95%CI), mean [10^th-90^th percentile], mean [Q 1^st-3^rd quartile];

^bAlso indicated in table is whether the parameters increase (↑), decrease (↓) due to the disease or stay constant. When more then one value is reported for the same reference, it concerns measurements at different time points. ES/BS: Eroded surface; E.De: Erosion depth; W.Th: Wall thickness; PmOP: Postmenopausal osteoporosis.