Incorporating GSA-SPECT into CT-based dose-volume histograms for advanced hepatocellular carcinoma radiotherapy

Figure 8 Quantitative analysis of radiation-induced dysfunctional liver. A: Computed tomographic image of a 52-year-old man with a recurrent tumor thrombus in the main portal vein after undergoing left hepatectomy for hepatocellular carcinoma; B: Isodose curves used for treatment planning; C: F_20Gy was calculated from the GSA count of the entire liver and the area within the 20 Gy isodose curve; D: F_{20 Gy} was calculated from a single photon emission computed tomography with Tc-99m-galactosyl human serum albumin image using the formula: F_{20 Gy} = 100 × (GSA count in the area of the liver within the 20 Gy isodose curve)/(GSA count for the entire liver); E: In this patient, F_20Gy was 22.2%. GSA: Galactosyl human serum albumin; DVH: Dose volume histogram; DFH: Dose function histogram; HCC: Hepatocellular carcinoma.