FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC

Table 4 Epidermal growth factor receptor

Ref.	Year of publication	n	EGFR selection	EGFR mutation (n)	Cut-off value	FDG	PFS
Riely et al[20]	2007	13	Only EGFR mutated tumors	8	n/a
Aukema et al[21]	2010	22	No selection	4	25%
Milishkin et al[11]	2011	51	No selection	4	> 15%	EGFR + PR 3 PD 2 SD 0 EGFR - PR SD PD
Zander et al[22]	2011	34	No selection	4			EGFR + 6.4 mo EGFR - 1.6 mo
Benz et al[23]	2011	22	No selection	5
O'Brien et al[24]	2012	47	No selection	11
Takahashi et al[25]	2012	20	No selection	12		EGFR+ PR 8 SD 3 PD 1 EGFR- PR SD PD

EGFR: Epidermal growth factor receptor; FDG: [¹⁸F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography; PFS: Progression free survival; n/a: Not applicable.