FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC

Table 3 Late [¹⁸F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography response > 21 d

Ref.	Year ofpublication	n	SUV	Responsecriteria	Cut-offvalue	FDG response time	FDG Responsen (%)	FDG-PET vs RECIST	PFS	OS
Mileshkin et al[11]	2011	51	Max	EORTC	15%	56 d	PR 8 (16) SD 12 (23) PD 31 (61)	FDG PR: PR 4 SD 4 PD 0 FDG SD: PR 0 SD 11 PD 1 FDG PD: PR 0 SD 11 PD 20	R 6.5 mo NR 2.7 mo	R 11.9 mo NR 7.6 mo
Zander et al[22]	2011	34	Peak	EORTC		42 d	n/a	n/a
Benz et al[23]	2011	22	Max	PRECIST		78 d	n/a	n/a
O'Brien et al[24]	2012	47	Max	EORTC	25%	42 d	PR 15 (32) SD 8 (17) PD 15 (32) NE 9 (19)	FDG PR: PR 11 SD 2 PD 2 FDG SD: PR 0 SD 4 PD 4 FDG PD: PR 0 SD 2 PD 7
Takahashi et al[25]	2012	20	Max	EORTC		28 d	n/a	n/a

FDG: [18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography; RECIST: Response Evaluation Criteria in Solid Tumors; PFS: Progression free survival; EORTC: European Organization for Research and Treatment of Cancer; n/a: Not applicable.