FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC

Table 1 Patient characteristics n(%)

Ref.	Year of publication	n	Age,yr	M/F	Study type	Study protocol FDG response	Stage ofdisease	Histology	EGFR Selection
Riely et al[20]	2007	13	56	2/11	Prospective	21 d after stopping and 21 d after restarting	IV	Adenocarcinoma 11 (85) Other (including NOS) 2 (15)	Only EGFR mutated tumors
Aukema et al[21]	2010	23	63	8/15	Prospective	After 7 d	I-III	Adenocarcinoma 17 (73) Other 6 (26)	No selection
Mileshkin et al[11]	2011	51	61	30/21	Prospective	After 14 d and 56 d	III - IV	Adenocarcinoma 37 (72) Squamous cell carcinoma 8 (16) Large-cell carcinoma 1 (2) Other (including NOS) 5 (10)	No selection
Zander et al[22]	2011	34	61	17/17	Prospective	After 7 d and 42 d	IV	Adenocarcinoma 26 (76) Squamous cell carcinoma 4 (12) Large cell carcinoma 1 (3) Bronchioloalveolar carcinoma 3 (9)	No selection
Benz et al[23]	2011	22	64	6/16	Prospective	After 14 d and 78 d	III - IV	Adenocarcinoma 17 (78) Squamous cell carcinoma 3 (14) Other (including NOS) 1 (4) Large cell carcinoma 1 (4)	No selection
O'Brien et al[24]	2012	47	63	18/29	Prospective	After 42 d	III - IV	Adenocarcinoma 28 (60) Squamous cell carcinoma 6 (13) Bronchioalveolar carcinoma 7 (14) Other (including NOS) 6 (13)	No selection
Takahashi et al[25]	2012	20	69	5/15	Prospective	After 2 d and 28 d	III - IV	Adenocarcinoma 20 (100)	No selection

FDG: [18F]-fluorodeoxyglucose; EGFR: Epidermal growth factor receptor.