Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders

doi:10.4329/wjr.v6.i10.756

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World Journal of Radiology

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1949-8470

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Radiol. Oct 28, 2014; 6(10): 756-778
Published online Oct 28, 2014. doi: 10.4329/wjr.v6.i10.756

Table 2 Obsessive compulsive disorder deep brain stimulation targets: Activation/deactivation of cortical and subcortical targets

	STN_DBS	ALIC_DBS	VCVS_DBS
Frontal cortex		↑Nuttin¹^a
Medial frontal gyrus	↓Le Jeune¹^f
Inferior frontal gyrus		↓Zuo¹^b
Supplementary motor area	↑Min^1b,5	↓Zuo²
Prefrontal cortex			↑ Knight^1d,7
Lateral PFC			↓Figee^1b,2,↓ Knight
Dorsolateral PFC	↑Min^1b,5		↑Sturm, ↑ Knight
Medial PFC	↓Le Jeune²		↓Figee^1a,2 , ↑ Knight
Cingulate			↑Sturm; ↑ Knight^1d,7
Anterior cingulate cortex	↑Min¹^b; ↓Le Jeune¹^f	↓Zuo^1b,2	↑ Knight¹^d; ↑Rauch¹^f
Orbitofrontal cortex	↓Le Jeune²	↓Zuo¹^b; ↓Abelson³	↑Rauch¹^f
Insula	↑Min¹^b		↑ Figee; ↑Knight^1d,6
Striatum		↑ Nuttin¹^a
Caudate	↑Min¹^b	↓Zuo¹^b	↑Figee
Putamen	↑Min¹^b		↑Figee; ↓Sturm;↑Rauch¹^f
Nucleus accumbens			↑Figee¹^c
Temporal cortex	↑ Min^1b,4
Superior temporal gyrus		↓Zuo¹^b ;↑Nuttin¹^a
Medial temporal gyrus		↑Nuttin¹^a
Thalamus	↑ Min^1b,4	↓Zuo¹^b	↑Figee; ↓Knight^1d,6; ↑Rauch¹^f
Pons			↑Nuttin¹^a
Hippocampus/parahippocampus	↑ Min^1b,4		↑ Knight^1d,6
Globus pallidus			↑ Rauch¹^f

¹Statistically significant,

^aP < 0.05,

^bP < 0.001,

^dP < 0.0001,

^fP < 0.005,

^cP = 0.031 vs scans;

²Statistically correlated with treatment response;

³Decreased activity for 2 of 3 patients; ⁴Significant activation to STN vs Gpi; ⁵Significant at 2 V; ⁶As the stimulation voltage increased from 3 V to 5 V, the region of BOLD signal modulation increased; ⁷As the stimulation voltage increased from 3 V to 5 V, the region of BOLD signal modulation area decreased for n = 2 pigs. STN: Subthalamic nucleus; ALIC: Anterior capsulotomy of anterior limb of internal capsules; DBS: Deep brain stimulation; VCVS: Ventral (anterior internal) capsule/ventral striatum; BOLD: Blood oxygen level dependent; PFC: Prefrontal cortex.

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Citation: Williams NR, Taylor JJ, Lamb K, Hanlon CA, Short EB, George MS. Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders. World J Radiol 2014; 6(10): 756-778
URL: https://www.wjgnet.com/1949-8470/full/v6/i10/756.htm
DOI: https://dx.doi.org/10.4329/wjr.v6.i10.756

Williams NR, Taylor JJ, Lamb K, Hanlon CA, Short EB, George MS. Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders. World J Radiol 2014; 6(10): 756-778 [PMID: 25349661 DOI: 10.4329/wjr.v6.i10.756]

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