Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

Figure 4 Dynamic changes in K^trans. The tumor (arrows) in rat liver showed an abundant blood supply with high K^trans before treatment (A); At 6 h after CA4P treatment, vascular shutdown was indicated with low K^trans in the center, surrounded by tumor residue at the periphery, with moderate K^trans (B); At 48 h after treatment, the tumor relapsed upon the residue at the periphery with rebounding K^trans (C).