Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

Figure 3 ADC_perfusion and initial area under the gadolinium curve in an implanted tumor in rat liver. At 48 h after iv treatment with CA4P at 10 mg/kg, obvious tumor recurrence with partial recovery of blood supply was demonstrated. The tumor (arrows) appeared hyperintense on T2WI (A) and hypointense on T1WI (B); On CE-T1WI, the tumor relapsed at the periphery, shown as ring enhancement of viable tumor cells (C); ADC_10b (derived from 10 b values from 0 to 1000 s/mm²) revealed the hyperintense necrotic center and isointense viable tumor rim (D); On ADC_perfusion (ADC_low-ADC_high) maps, the relative hyperintensity at the periphery suggested the partial recovery of perfusion, compared to the hypointensity in the necrotic center with perfusion deficit (E); ADC_perfusion matched well with CE-T1WI-overlyaed initial area under the gadolinium curve (IAUGC) map (F).