Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

Figure 2 In vivo magnetic resonance imaging findings of an implanted tumor in rat liver. Before treatment, the tumor (arrows) appeared hyperintense on T2WI (A1); hypointense on T1WI (A2); strongly enhanced on CE-T1WI (A3); and slightly hypointense on ADC_high (b = 500, 750, 1000 s/mm²) (A4). At 24 h after the intravenous treatment with CA4P at 10 mg/kg, obvious vascular shutdown was observed. The tumor (arrows) was still hyperintense on T2WI (B1) and hypointense on T1WI (B2). On CE-T1WI, the tumor (arrow) appeared hypointense in the center with an enhanced rim of viable neoplastic cells (B3). On ADC_high map (B4), the hyperintensity in the center corresponded to necrosis, and the isointense ring was concordant with the viable tumor rim (arrow) on CE-T1WI. Note the viable tumor nodule at the periphery, shown as hyperintensity (arrowhead) on CE-T1WI (B3), and hypointensity (arrowhead) on ADC_high (B4).