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Copyright: ©Author(s) 2026.
World J Radiol. Aug 28, 2026; 18(8): 121065
Published online Aug 28, 2026. doi: 10.4329/wjr.121065
Table 7 Image Biomarker Standardisation Initiative standardization framework: Key phases and achievements
Phase
Timeline
Key achievements
Impact on reproducibility
IBSI phase 12016-2020Standardized definitions for > 170 features; digital phantoms; benchmark values across multiple software platformsEstablished common mathematical language; enabled cross-platform comparison
IBSI phase 2Completed February 2024Formalized preprocessing workflow (discretization, interpolation, filtering); expanded test phantoms for CT, MRI, PET pipelinesEntropy coefficient of variation decreased from 34% to 7%
Reporting guidelinesOngoingTransparent documentation of discretization, filtering, ROI handling, feature selection rationaleImproved study reproducibility and meta-analytic comparability
Compliance toolsAvailableOnline validation portal; excel-based reference sheets; benchmark feature valuesSoftware platforms (PyRadiomics, LIFEx, SERA, RaCaT) can verify compliance


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