Radiolabeled exosomes for theranostics: Personalized tailored therapy through imaging

Figure 2 Schematic representation of indirect radiolabeling strategies. Exosomes released from cells contain several biological materials, such as proteins, lipids, and nucleic acids, which can be utilized as binding or entry sites for radiolabels. Indirect labeling incorporates radiotracers into exosomes through chelation, electrostatic binding, lipid insertion, or carrier-mediated (bio-orthogonal) methods, enabling stable, noninvasive positron emission tomography/single-photon emission computed tomography imaging tracking without compromising vesicle integrity. Created in BioRender, https://BioRender.com/278r8w1. Science Suite Inc. dba BioRender (“BioRender”) has granted Prakash Gangadaran permission to use this Completed Graphic in accordance with BioRender’s Terms of Service and Academic License Terms (“License Terms”).