Computed tomography radiomics-based machine learning nomogram for preoperative prediction of glypican-3 expression in hepatocellular carcinoma

Table 4 Univariate and multivariate analysis of clinical and computed tomography imaging features

Characteristics	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	OR	95%CI	P value
Age	1.005	0.995-1.015	0.377
CEA (ng/mL)	0.998	0.995-1.001	0.357
Sex	1.034	0.797-1.342	0.832
Viral hepatitis	1.190	0.975-1.452	0.150
TBIL (μmol/L)	0.638	0.535-0.759	< 0.001	0.636	0.549-0.738	< 0.001
DBIL (μmol/L)	0.819	0.676-0.991	0.086
IBIL (μmol/L)	0.934	0.770-1.134	0.560
ALT (U/L)	0.935	0.764-1.145	0.582
AST (U/L)	0.890	0.733-1.081	0.322
TP (g/L)	0.801	0.643-0.998	0.097
ALB (g/L)	0.989	0.799-1.224	0.931
GLB (g/L)	0.855	0.629-1.163	0.400
AFP (ng/mL)	0.627	0.529-0.744	< 0.001	0.626	0.541-0.725	< 0.001
Liver cirrhosis	0.840	0.689-1.025	1.150
Ascites	0.797	0.546-1.165	0.322
Portal vein tumor thrombus	0.938	0.700-1.259	0.719

OR: Odds ratio; CEA: Carcinoembryonic antigen; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TP: Total protein; ALB: Albumin; GLB: Globulin; AFP: Alpha-fetoprotein.