Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers

doi:10.4329/wjr.v18.i3.117599

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World Journal of Radiology

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1949-8470

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Radiol. Mar 28, 2026; 18(3): 117599
Published online Mar 28, 2026. doi: 10.4329/wjr.v18.i3.117599

Table 4 Model efficacy in predicting clinical response to vedolizumab

Model	AUC	Sensitivity	Specificity	PPV	NPV
Training cohort
Combined model	0.757 (0.65-0.863)	72.4% (42/58)	74.3% (26/35)	82.4% (42/51)	61.9% (26/42)
Radiomics model	0.646 (0.522-0.769)	67.2% (39/58)	62.9% (22/35)	75.0% (39/52)	53.7% (22/41)
Clinical model	0.731 (0.626-0.835)	55.2% (32/58)	82.9% (29/35)	84.2% (32/38)	52.7% (29/55)
Validation cohort
Combined model	0.721 (0.56-0.883)	76.2% (16/21)	70.0% (14/20)	72.7% (16/22)	73.7% (14/19)
Radiomics model	0.819 (0.687-0.951)	81.0% (17/21)	75.0% (15/20)	77.3% (17/22)	78.9% (15/19)
Clinical model	0.79 (0.654-0.927)	52.4% (11/21)	90.0% (18/20)	84.6% (11/13)	64.3% (18/28)

AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value.

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Citation: Zhang XY, Li YK, Tian ZB, Guo QY, Liu JN, Liu RQ, Ren KY. Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers. World J Radiol 2026; 18(3): 117599
URL: https://www.wjgnet.com/1949-8470/full/v18/i3/117599.htm
DOI: https://dx.doi.org/10.4329/wjr.v18.i3.117599

Zhang XY, Li YK, Tian ZB, Guo QY, Liu JN, Liu RQ, Ren KY. Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers. World J Radiol 2026; 18(3): 117599 [PMID: 41937988 DOI: 10.4329/wjr.v18.i3.117599]

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