Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers

doi:10.4329/wjr.v18.i3.117599

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World Journal of Radiology

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1949-8470

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Radiol. Mar 28, 2026; 18(3): 117599
Published online Mar 28, 2026. doi: 10.4329/wjr.v18.i3.117599

Table 2 Results of univariate logistic regression analysis

Variables	β	SE	Z	P value	OR (95%CI)
SM	0.00	0.01	0.43	0.665	1.00 (0.99-1.02)
IMAT	0.02	0.03	0.63	0.532	1.02 (0.96-1.07)
SAT	-0.00	0.00	-0.96	0.338	1.00 (0.99-1.00)
VAT	0.00	0.00	0.65	0.519	1.00 (1.00-1.01)
HB	0.01	0.01	1.01	0.312	1.01 (0.99-1.02)
WBC	-0.01	0.06	-0.11	0.911	0.99 (0.88-1.12)
P	-0.00	0.00	-1.10	0.273	1.00 (0.99-1.00)
ESR	-0.01	0.01	-0.89	0.375	0.99 (0.97-1.01)
CRP	0.02	0.01	1.74	0.081	1.02 (1.00-1.04)
ALB	0.04	0.04	1.13	0.259	1.04 (0.97-1.12)
N	0.06	0.08	0.76	0.450	1.06 (0.91-1.24)
L	-0.86	0.41	-2.10	0.036	0.42 (0.19-0.94)
M	-0.53	0.73	-0.73	0.468	0.59 (0.14-2.47)
Smoking history
0	-	-	-	-	1.00 (reference)
1	-0.58	0.62	-0.94	0.348	0.56 (0.16-1.89)
UC Montreal classification
E1	-	-	-	-	1.00 (reference)
E2	-15.45	1029.12	-0.02	0.988	0.00 (0.00-Inf)
E3	-15.01	1029.12	-0.01	0.988	0.00 (0.00-Inf)
Mayo score	-0.80	0.70	-1.15	0.252	0.45 (0.11-1.76)
TSpot
0	-	-	-	-	1.00 (reference)
1	-0.41	0.60	-0.68	0.496	0.66 (0.20-2.16)
Age	-0.00	0.01	-0.25	0.806	1.00 (0.97-1.03)
BMI	0.03	0.07	0.39	0.695	1.03 (0.90-1.18)
Modified Mayo Score	-0.19	0.13	-1.41	0.159	0.83 (0.64-1.08)

OR: Odds ratio; CI: Confidence interval; SM: Skeletal muscle; IMAT: Intramuscular adipose tissue; SAT: Subcutaneous adipose tissue; VAT: Visceral adipose tissue; HB: Hemoglobin; WBC: White blood cell; P: Platelet; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; ALB: Albumin; N: Neutrophil; L: Lymphocyte; M: Monocyte; UC: Ulcerative colitis; BMI: Body mass index; TSpot: T-Spot.TB.

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Citation: Zhang XY, Li YK, Tian ZB, Guo QY, Liu JN, Liu RQ, Ren KY. Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers. World J Radiol 2026; 18(3): 117599
URL: https://www.wjgnet.com/1949-8470/full/v18/i3/117599.htm
DOI: https://dx.doi.org/10.4329/wjr.v18.i3.117599

Zhang XY, Li YK, Tian ZB, Guo QY, Liu JN, Liu RQ, Ren KY. Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers. World J Radiol 2026; 18(3): 117599 [PMID: 41937988 DOI: 10.4329/wjr.v18.i3.117599]

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