Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy

doi:10.4329/wjr.v18.i2.116973

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World Journal of Radiology

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1949-8470

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Radiol. Feb 28, 2026; 18(2): 116973
Published online Feb 28, 2026. doi: 10.4329/wjr.v18.i2.116973

Table 2 Regions with significant differences showing cerebral blood flowand amplitude of low-frequency fluctuation

Group	Brain regions	MNI coordinates (mm)			Volume (mm³)	Peak (t-value)
Group	Brain regions	X	Y	Z	Volume (mm³)	Peak (t-value)
Comparison results of CBF differences
Before-HC	R. orbitofrontal superior gyrus	9	66	-12	1056	-4.62
	L. superior temporal gyrus	-60	-27	18	537	-3.96
1 m-before	L. fusiform gyrus	-30	-39	-18	5280	+6.56
3 m-1 m	R. fusiform gyrus	39	-33	-21	512	-4.39
	L. angular gyrus	-45	-63	51	587	+7.93
Comparison results of ALFF differences
Before-HC	L. superior temporal gyrus	-39	-33	12	1502	-6.68
	L. opercular part of inferior frontal gyrus	-48	9	21	213	-6.36
	R. precuneus	15	-60	21	3765	-6.04
1 m-before	L. superior temporal gyrus	-48	-30	21	687	+4.68
3 m-before	L. orbitofrontal superior gyrus	-6	51	-6	298	+5.95
	L. precuneus	-3	-75	51	458	+7.69
3 m-1 m	R. insula	36	-27	18	513	-6.43
	Cerebelum_Crus1_L	-24	-72	-33	851	-6.64

Positive sign in the peak t-score represents increase, and negative sign represents decrease; All P < 0.05, corrected for Gaussian random field. Before: Preoperative transjugular intrahepatic portosystemic shunts; HC: Healthy control group; 1 m: Postoperative transjugular intrahepatic portosystemic shunts at 1 month; 3 m: Postoperative transjugular intrahepatic portosystemic shunts at 3 months; CBF: Cerebral blood flow; ALFF: Amplitude of low-frequency fluctuation; R.: Right; L.: Left; MNI: Montreal Neurological Institute.

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Citation: Zhuang WL, Xu SW, Fang J, Zhang ZQ, Zhang SA, Wang JL, Zheng JL, Wang XY, Li DL. Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy. World J Radiol 2026; 18(2): 116973
URL: https://www.wjgnet.com/1949-8470/full/v18/i2/116973.htm
DOI: https://dx.doi.org/10.4329/wjr.v18.i2.116973

Zhuang WL, Xu SW, Fang J, Zhang ZQ, Zhang SA, Wang JL, Zheng JL, Wang XY, Li DL. Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy. World J Radiol 2026; 18(2): 116973 [PMID: 41809706 DOI: 10.4329/wjr.v18.i2.116973]

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