Imaging biomarkers for detection and longitudinal monitoring of ventricular abnormalities from birth to childhood

Figure 1 Levene’s index. Coronal ultrasound and coronal magnetic resonance imaging (MRI) images at the level of the foramen of Monro illustrating Levene’s index. The measurement corresponds to the distance from the midline to the lateral wall of the anterior horn of the lateral ventricle (yellow arrow). A: Normal Levene’s index in a preterm infant (33 + 4 weeks) on coronal ultrasound; B: Normal Levene’s index in a 3-year-old child on coronal fluid-attenuated inversion recovery (FLAIR) MRI; C: Increased Levene’s index in a preterm infant (26 + 1 weeks) with hydrocephalus secondary to germinal matrix hemorrhage on coronal ultrasound; D: Increased Levene’s index in a 3-year-old child with asymmetric biventricular hydrocephalus due to perinatal ischemia on coronal FLAIR MRI.