Treatment of a rare and severe infection of central nervous system by Angiostrongylus cantonensis: A case report

Table 3 Summary of cerebrospinal fluid test results

Item	November 11, 2023	November 16, 2023	November 22, 2023	November 30, 2023	December 19, 2023
Routine	Colorless and slightly turbid; total cell count: 506 × 106/L; total WBC: 491 × 106/L; multinucleated to mononucleated cell ratio: 0.75; qualitative protein test: Positive	Colorless and transparent; total cell count: 171 × 106/L; total WBC: 145 × 106/L; multinucleated to mononucleated cell ratio: 0.27; qualitative protein test: Positive	Colorless and transparent; total cell count: 90 × 106/L; total WBC: 88 × 106/L; multinucleated to mononucleated cell ratio: 0.45; qualitative protein test: Positive	Colorless and transparent; total cell count: 65 × 106/L; total WBC: 59 × 106/L; multinucleated to mononucleated cell ratio: 0.08; qualitative protein test: Positive	Colorless and transparent; total cell count: 252 × 106/L; total WBC: 88 × 106/L; multinucleated to mononucleated cell ratio: 0.08; qualitative protein test: Positive
Biochemical test	Glu 2.36 mmol/L (decrease); chloride 1183 mmol/L (decrease); protein 980 mmol/L (increase)	Glu 2.51 mmol/L (decrease); chloride 1195 mmol/L; protein 1023 mmol/L (increase)	Glu 3.22 mmol/L (decrease); chloride 1209 mmol/L; protein 574 mmol/L (increase)	Glu 2.87 mmol/L; chloride 121 mmol/L; protein 604 mmol/L (increase)	Glu 3.02 mmol/L; chloride 1233 mmol/L; protein 412 mmol/L (increase)
Ig determination	IgA 1.8 mg/dL (increase); IgG 33.5 mg/dL (increase); IgM 9.8 mg/dL (increase)	IgA 1.0 mg/dL (increase); IgG 32.1 mg/dL (increase); IgM 16.8 mg/dL (increase)	IgA 0.5 mg/dL; IgG 19.2 mg/dL (increase); IgM 5.2 mg/dL (increase)	IgA 2.4 mg/dL (increase); IgG 17.9 mg/dL (increase); IgM 0.3 mg/dL (increase)	IgA 1.2 mg/dL (increase); IgG 10 mg/dL (increase); IgM 1.7 mg/dL (increase)
TORCH	Absent	Absent	Absent	Absent	Absent
Pathogen detection	Negative	Negative	Negative	Negative	Negative
Bedside ROSE	No bacteria, fungi, or parasites found. Predominantly mononuclear cells with eosinophils being approximately 40%	No bacteria, fungi, or parasites found. Predominantly mononuclear cells with eosinophils being approximately 11.1%	Absent	Absent	Absent
M. tuberculosis nucleic acid PCR test	Absent	Absent	Absent	Absent	Absent
M. tuberculosis and rifampicin resistance gene testing	Absent	Absent	Absent	Absent	Absent
NGS test in this hospital	Absent	Negative	Absent	Absent	Absent
KingMed NGS test	Absent	Absent	Absent	Angiostrongylus cantonensis (sequences 10429)	Angiostrongylus cantonensis (sequences 1003)

Glu: Glucose; Ig: Immunoglobulin; TORCH: Toxoplasma, other pathogens, rubella virus, cytomegalovirus, and herpes simplex virus; NGS: Next-generation sequencing; M. tuberculosis: Mycobacterium tuberculosis; PCR: Polymerase chain reaction; ROSE: Rapid on site evaluation; WBC: White blood cell.