Update report on the quality of gliomas radiomics: An integration of bibliometric and radiomics quality score

Table 4 Subgroup analysis in the goal of research, median (interquartile range)

Radiomics quality score	Differential diagnosis	Treatment response	Prognosis prediction	Grading or molecular typing	P value
Total 36 points	10 (8–13)	11 (8–14)	13 (11–15)	11 (9–15)	0
Domain 1: Protocol quality and stability in image and segmentation (0 to 5 points)	2 (1–2)	2 (1–2)	1 (1–2)	1 (1–2)	0.006
Image protocol quality (2)	1 (1–1)	1 (1–1)	1 (1–1)	1 (1–1)	< 0.001
Multiple segmentations (1)	1 (1–1)	0 (0–1)	0 (0–0.75)	1 (0–1)	< 0.001
Phantom study on all scanners (1)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0.002
Imaging at multiple time points (1)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0.36
Domain 2: Feature selection and validation (-8 to 8 points)	5 (–2–5)	5 (–2–6)	5 (5–6)	5 (5–5)	0.012
Feature reduction or adjustment for multiple testing (-3 or 3)	3 (3–3)	3 (3–3)	3 (3–3)	3 (3–3)	0.601
Validation (-5, 2, 3, 4, or 5)	2 (–5–2)	2 (2–2)	2 (2–3)	2 (–5–3)	0.007
Domain 3: Biologic/clinical validation and utility (0 to 6 points)	2 (0–2)	1 (1–2)	1 (1–2)	2 (0–2)	0.18
Multivariable analysis with non-radiomics features (1)	0 (0–0)	1 (0–1)	1 (1–1)	1 (0–1)	< 0.001
Detect and discuss biological correlates (1)	0 (0–0)	0 (0–0)	0 (–0–1)	0 (0–1)	0.001
Comparison to ‘gold standard’ (2)	0 (0–2)	0 (0–0)	0 (0–0)	0 (0–0)	< 0.001
Potential clinical utility (2)	0 (0–2)	0 (0–0)	0 (0–0)	0 (0–0)	0.032
Domain 4: Model performance index (0 to 5 points)	2 (2–2)	3 (2–4)	4 (3–5)	3 (2–4)	< 0.001
Cut-off analyses (1)	0 (0–1)	0 (0–1)	1 (1–1)	0 (0–1)	< 0.001
Discrimination statistics (2)	2 (1.5–2)	2 (2–2)	2 (1–2)	2 (1–2)	0.049
Calibration statistics (2)	0 (0–0)	0 (0–2)	0 (1–2)	0 (0–2)	< 0.001
Domain 5: High level of evidence (0 to 8 points)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0.001
Prospective study registered in a trial database (7)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0.148
Cost-effectiveness analysis (1)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	< 0.001
Domain 6: Open science and data (0 to 4 points)	0 (0–1)	1 (0–1)	1 (0–1)	0 (0–1)	0.016