Multi-modality imaging of cardiac amyloidosis: Contemporary update

Table 5 Strengths and limitations of each imaging modality for assessing cardiac amyloidosis

Modality	Echocardiography	Magnetic resonance imaging	Nuclear imaging
Strengths	Availability and portable	Lack of radiation	Distinguishing between AL/ATTR
	Low cost	High spatial resolution
	Lack of radiation	Chamber quantification
	Lack of contrast	Tissue characterization
	Chamber quantification	Quantifying myocardial fibrosis
	Diastolic function
	Strain
Weaknesses	Variable spatial resolution	Higher cost	Higher cost
	Low specificity	Availability may be limited	Availability may be limited
	No tissue characterization	Gadolinium-based contrast administration	Radiation exposure
	Not distinguish AL/ATTR	Claustrophobia
	Not able to assess and quantify myocardial fibrosis	Metallic device
		Not able to distinguish between AL/ATTR

AL: Light chain amyloidosis; ATTR: Transthyretin amyloidosis.