High-resolution computed tomography findings in humoral primary immunodeficiencies and correlation with pulmonary function tests

Table 2 Prevalence of high-resolution computed tomography-detected abnormalities in the two humoral primary immunodeficiencies subtypes (CVID and CVID-like), and comparison between the two groups n (%)

Abnormality	All patients n = 52	CVID n = 38	CVID-like n = 14	P-value (CVID vs CVID-like)
Airway abnormalities
Bronchiectasis	36 (69.2)	27 (71)	9 (64.3)	0.8964
Airway wall thickening	37 (71.2)	27 (71)	10 (71.4)	0.7501
Tree-in-bud	10 (19.2)	6 (15.8)	4 (28.6)	0.8464
Mucus plugging	23 (44.2)	16 (42.1)	7 (50)	0.8888
Air trapping1	16 (50)	12 (52.2)	4 (44.4)	0.8557
Parenchymal-interstitial abnormalities
Consolidation	14 (26.9)	11 (28.9)	3 (21.4)	0.8495
Ground-glass opacity	13 (25)	12 (31.6)	1 (7.1)	0.1487
Nodules	26 (50)	19 (50)	7 (50)	1
Linear and/or irregular opacities	12 (23.1)	12 (31.6)	0 (0)a	0.0427
Bullae/cysts	5 (9.6)	5 (13.2)	0 (0)	0.3695

^aP <0.05.

¹Values are calculated on the 32 patients (23 CVID + 9 CVID-like) for whom additional expiratory scan was acquired. Chi-square test: CVID vs CVID-like patients; CVID: Common variable immunodeficiency disorders; CVID-like: Including isolated IgG subclass deficiency and selective IgA deficiency.