Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner

Table 1 Cardiac function in dominant negative cyclic AMP response-element binding protein/interleukin-19 KO double transgenic male and female mice¹

		LVID; d (mm)	LVID; s (mm)	FS (%)	SV (μL)	HR (bpm)	CO (mL/min)
DTG	Male	4.49 ± 0.47	3.90 ± 0.60	13.95 ± 4.2	24.10 ± 2.60	566 ± 30	13.59 ± 1.33
	Female	4.53 ± 0.18	3.99 ± 0.29	12.02 ± 3.05	23.34 ± 3.11	621 ± 24	14.35 ± 1.30

¹Values are presented as mean ± SEM. Animals are 10 wk of age; n = 3 of each sex. All comparisons between sexes are P > 0.05 as assessed by Student’s t-test. LVID; d: Left ventricular internal diameter at diastole; LVID; s: Left ventricular internal diameter at systole; FS: Fractional shortening; SV: Stroke volume; HR: Heart rate; CO: Cardiac output. DTG: Double transgenic.