Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach

Figure 4 Two-dimensional gel electrophoresis of heart lysates from 12-wk-old mice. Comparative proteomics analysis revealed 10 non-redundant proteins in KI (heterozygote mutant) vs WT controls (A), 8 non-redundant proteins in KO (homozygote mutant) vs WT mouse hearts (B); 19 non-redundant protein changes in KO vs KI (C). Arrows indicate differential phisphorylation of proteins in WT vs KO and KI vs KO mice hearts (B and C, respectively).