Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach

Table 3 Differentially expressed proteins identified by MALDI MS-MS

No.	Protein code	Gene ID	KI/WT	KO/WT	KO/KI	Pathways
1	PKP1	18772	1.76	-1.13	-1.99	Focal adhesion, apoptosis
2	HRC	15464	1.62	1.06	-1.53	Calcium signaling
4	PYGB	53313	1.61	1.16	-1.39	Glucagon signaling, insulin signaling
5	MSN1	17698	-2.68	4.71	12.57	Cell shape, actin-cytoskeleton
6	VINC	22330	-4.18	4.96	20.64	Cell-cell adhesion, cell shape, actin cytoskeleton
8	SYNE11	64009	-3.59	5.82	20.82	Nucleus-cytoskeleton connection
14	ADAM10	11487	1.71	-1.18	-2.02	Inflammation, amiloidosis
17	TNPO3	320938	-1.11	1.51	1.67	Nucleus-cytoskeleton connection
18	CAPN8	170725	2.15	-1.02	-2.19	Inflammation
19	CGNL1	68178	1.58	-1.03	-1.63	Focal adhesion
20	VIM	22352	1.43	1.40	-1.02	Cell division, fibrosis
23	MYH6	17888	1.02	-3.41	-3.49	Sarcomere, actin-cytoskeleton
24	NRAP	18175	-1.03	1.79	1.84	Focal adhesion, actin cytoskeleton
28	ANXA3	20480	1.23	-1.80	-2.23	Prostaglandin synthesis and regulation
29	LATS2	23805	-1.58	-1.51	1.04	Hippo signaling pathway, DNA damage
32	SPTB1	20741	1.56	-1.01	-1.59	Actin-cytoskeleton
33	GCC2	11426	1.04	-3.78	-3.92	Vesicle-mediated transport, retrograde transport at the trans-Golgi-network
37	ACADS	12306	-2.01	1.12	2.24	Mitochondrial fatty acid beta-oxidation
39	FHL2	14200	1.05	-2.25	-2.37	Focal adhesion, Wnt, calcineurin signaling
39	MYOZ2	59006	1.05	-2.25	-2.37	Cytoskeleton, calcineurin signaling, myofibrillogenesis
47	FGF9	14180	2.93	5.90	2.01	Fibrosis
53	DST	13518	2.23	1.01	-2.21	Focal adhesion, actin cytoskeleton
59	FEZ2	56069	1.89	-1.11	-2.12	N/A
59	CSRP3	13009	1.89	-1.11	-2.12	Stress sensing, myogenesis
62	MYOM1	319565	-1.37	1.58	2.15	Striated muscle contraction
63	MYOM2	17930			+++	Sarcomere
65	EZR/MSN	17698			+++	Cell surface organization, adhesion, microtubule

¹Genes with statistically significant correlation with that of Mypn in mouse hearts. KI: Knock-in Mypn mouse; KO: Knock-out Mypn mouse; WT: Wild type littermates; -: Proteins downregulated compared to WT; +++: Proteins with differentially phosphorylated proteins in KI vs KO; N/A: Not applicable.