Endothelial progenitor cells: Exploring the pleiotropic effects of statins

doi:10.4330/wjc.v9.i1.1

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Jan 26, 2017 (publication date) through Jun 16, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Jan 26, 2017; 9(1): 1-13
Published online Jan 26, 2017. doi: 10.4330/wjc.v9.i1.1

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Figure 1 Simplified diagram illustrating the positive and negative effects on endothelial progenitor cell proliferation, mobilisation and longevity together with proposed mechanisms of action of statin therapy. EPC: Endothelial progenitor cell; NO: Nitric oxide; eNOS: Endothelial nitric oxide synthase; VEGF: Vascular endothelial growth factor; mRNA: Messenger ribonucleic acid; TNF: Tumor necrosis factor alpha; IL-1: Interleukin 1; P13k-AKT: Phosphoinositide 3-kinase - protein kinase B pathway; NAD(P)H oxidase: Nicotinamide adenine dinucleotide phosphate-oxidase; miR : Micro non-coding ribonucleic acid.

Citation: Sandhu K, Mamas M, Butler R. Endothelial progenitor cells: Exploring the pleiotropic effects of statins. World J Cardiol 2017; 9(1): 1-13
URL: https://www.wjgnet.com/1949-8462/full/v9/i1/1.htm
DOI: https://dx.doi.org/10.4330/wjc.v9.i1.1