Recent advances in the diagnosis and treatment of acute myocardial infarction

Table 6 Stem cells in the treatment of patients with acute myocardial infarction

Ref.	n	Random-ized	Timepost MI	Cell dose	Baseline	LVEF	Duration	Other findings
Strauer et al[232]	20	Cohort	8 d	2.8 ± 2.2 × 107	57% ± 8%	5%	3 mo	↑ Regional but not global LVEF ↓ LV ESV and infarct size
Bartunek et al[216]	35	Cohort	10 d	12.6 ± 2.2 × 106	45% ± 2.5%	7%	4 mo	↑ LV regional function, ↑ perfusion; ↑↑ restenosis
Li et al[234]	70	Yes	6 d	7.3 ± 7.3 × 107	50 ± 8.2	7%	6 mo	↓ LV ESV, LV wall motion score
Janssens et al[221]	67	Yes	1 d	172 × 106	48.5 ± 7.2	3.30%	4 mo	↓ Infarct size
Meyer et al[226] and Wollert et al[237]	60	Yes	4.8 d	24.6 × 108	50.0 ± 10.0	=	6-18 mo	↑ LVEF at 6 but not at 18 mo
Kang et al[222]	96	Yes	4 d	1-2 × 109	52.0 ± 9.9	5.1% AMI	6 mo	↓ LV ESV and infarction in acute MI; = ESV and = old MI
Lunde et al[224,225]	100	Yes	6 d	68 × 106	41.3 ± 11.0	=	6-12 mo	LVEF ↑ in treated and controls; = EDV and infarct size
Ge et al[219]	20	Yes	1 d	4 × 107	53.8 ± 9.2	4.80%	6 mo	↑ LV regional wall perfusion by SPECT
Meluzín et al[235,236]	66	Yes	5-9 d	107-108	42 ± 0.0	3-5	3-12 mo	↑ LVEF 3% @107↑ LVEF 5%-7% @ 108 3-12 mo
Schächinger et al[230,231]	204	Yes	3-8 d	2.4 × 108	48.3 ± 9.2	6-7	4-12 mo	↑ EF when Rx > 4 d post MI and when EF < 48.9%; ↑ LV perfusion

Adapted from Henning[213]. MI: Myocardial infarctions; LVEF: Left ventricular ejection fraction.