Translational research of adult stem cell therapy

doi:10.4330/wjc.v7.i11.707

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Nov 26, 2015; 7(11): 707-718
Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.707

Table 2 Alternative strategies of stem cell therapy

Enhancement of cell survival, mobilization and paracrine secretion

Pharmacology (Statins, etc.)

Genetic modification (Akt and Ang1, VEGF and SDF-1, HO-1, bFGF/IGF-1/BMP2)

Preconditioning (Hypoxia, TLR3 stimulation)

Combination of different cell types or delivery approaches

MSCs and CSCs

Stop-flow (infarct area) and global intracoronary infusion (viable area)

Others

Cell infusion immediate after revascularization (allogeneic MSCs, CDCs, etc.)

Repeated cell infusion

Stimulation of exosome release

Direct exosome (or microRNAs) injection

Cell therapy in hypertrophied myocardium or dysfunction due to congenital heart disease

MSCs: Mesenchymal stem cells; CSCs: Cardiac stem cells; CDCs: Cardiosphere-derived cells; VEGF: Vascular endothelial growth factor; SDF: Stromal cell-derived factor; bFGF: Basic fibroblast growth factor; IGF: Insulin-like growth factor; BMP2: Bone morphogenetic protein 2; HO-1: Heme-oxygenase 1; Ang1: Angiopoietin 1.

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Citation: Suzuki G. Translational research of adult stem cell therapy. World J Cardiol 2015; 7(11): 707-718
URL: https://www.wjgnet.com/1949-8462/full/v7/i11/707.htm
DOI: https://dx.doi.org/10.4330/wjc.v7.i11.707

Suzuki G. Translational research of adult stem cell therapy. World J Cardiol 2015; 7(11): 707-718 [PMID: 26635920 DOI: 10.4330/wjc.v7.i11.707]

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