Renal sympathetic nervous system and the effects of denervation on renal arteries

Table 1 Different techniques of renal denervation

Approach	Technique	Device	Study	Follow-up	Outcome
Invasive	RF ablation	Balloon:
		OneShot	Renal hypertension ablation system trial[69]	12 mo	Average reduction in BP = 30.6 ± 22.0
		Vessix	REDUCE-HTN	Ongoing
		Non-balloon:
		Simplicity	SIMPLICITYI[35]	24 mo	32/14
			SIMPLICITYII[62]	6 mo	32/12
			SIMPLICITYIII	Ongoing trial
		Spiral	Renal hypertension ablation system trial[69]	12 mo	Average reduction in BP = 30.6 ± 22.0
		EnligHTN	EnligHTN I trial[70]	6 mo	Reduction in BP-26/10
	Ultrasound	Paradise	REALISE[71]	3 mo	Reduction in BP 22/12
		TIVUS	TIVUS I	Ongoing study
Non-invasive	Ultrasound	Verve
	Chemical	Cisplatin	Salman[72]	Animal study
		Vincristine	Silva	Animal study
		Guanethidine	Koistinaho[73]	Animal study
		Neurotoxin	Apex nano nanomagnetic therapy	Animal studies
	Other	Beta radiation cath	Novoste[74]