Essential hypertension and oxidative stress: New insights

Figure 1 Schematic summary of the role of vascular oxidative stress in the pathogenesis of hypertension and the mechanisms of exogenous antioxidant accounting for anti-hypertensive effects. AT-II: Angiotensin II; AT₁R: Type 1 angiotensin II receptor; ET-1: Endothelin 1; ET_AR: Type A endothelin receptor; UT-II: Urotensin II; UTR: Urotensin-II receptor; NO: Nitric oxide; eNOS: Endothelial nitric oxide synthase; PGI₂: Prostacyclin; NAC: N-Acetylcysteine; NOX: NADPH oxidase; NF-κB: Nuclear factor kappa B.