G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease

Table 1 Primary effects of G-protein-coupled estrogen receptor activation on coronary arteries

Effect	Species	Drug
Relaxation	Porcine	G-1[36,46]
		ICI182,780[35,36]
		Raloxifene[37]
		Tamoxifen[73]
	Rabbit	Raloxifene[54]
		Tamoxifen[74]
Endothelial NO production	Porcine	G-1[36]
		Raloxifene[54]
		Tamoxifen[74]
CASMC BKCa channel opening	Porcine	G-1[46]
		Raloxifene[37]
		Tamoxifen[10]
	Human	G-1[46]
Inhibition of CASMC proliferation	Porcine	G-1[47]
	Human	G-1[47]
Inhibition of CASMC migration	Porcine	G-1[47]

CASMC: Coronary artery smooth muscle cells; BK_Ca: G-1 opens calcium-activated potassium; NO: Nitric oxide.