Turning scar into muscle

Table 1 Advances in cell reprogramming

Year	Major advances	Ref.
2006	First report to demonstrate that it was possible to reprogram mouse somatic cells to a pluripotent state through the overexpression of 4 transcription factors	[2]
2007	Reprogramming of human cells to a pluripotent state was achieved	[6,7]
2008	First evidence of direct reprogramming of somatic cells from the same organ (pancreatic exocrine cells to beta-cells) without a pluripotency step	[8]
2010	First report of direct reprogramming of somatic cells into an unrelated tissue (tail-tip fibroblasts to neurons)	[9]
2010	Direct reprogramming of somatic cells to cardiomyocytes through the overexpression of 3 cardiac transcription factors was reported	[1]
2012	In vivo direct reprogramming of fibroblasts to cardiomyocytes was demonstrated through the injection of viral vectors into infarcted myocardium	[3,4]
2012	First report of direct reprogramming of somatic cells to cardiomyocytes by microRNAs	[5]