Review
Copyright ©2010 Baishideng Publishing Group Co.
World J Cardiol. Sep 26, 2010; 2(9): 280-288
Published online Sep 26, 2010. doi: 10.4330/wjc.v2.i9.280
Table 1 Cyclooxygenase-independent effects of aspirin
On platelets
Partially inhibits ADP2Y12 receptor activation responsible for residual arachidonic acid induced platelet activation[11]
Blocks NF-κB activation that facilitates platelet inhibition by neutrophils[12]
Anti-inflammatory effect
Inhibits release of reactive oxygen species[13]
Inhibits release of elastase and soluble ICAM-1[13]
Inhibits formation of malondialdehyde[13]
Inhibits formation of oxidized LDL antibodies[14]
Reduces inflammatory cell activity[13]
Anti-oxidant effect
Inhibits oxidized LDL formation[14]
Blocks transcription of LOX-1[15,16]
Scavenges hydroxyl radicals[17]
Induces synthesis of ferritin[18]
Inhibits nitric oxide synthase[19,20]
Inhibits expression of redox sensitive transcription factor NF-κB[19,20]
Acetylates proteins and prevents their oxidation[21,22]
Endothelial function modification
Prevents adhesion of neutrophils and monocytes[23]
Induction of VCAM-1, ICAM-1 and E-selectin[24,25]
Miscellaneous effects
Inhibits vascular smooth muscle cell function[26]
Inhibits angiogenesis[27-29]
Inhibits γ-carboxylation of coagulation factors[30]
ADP: Adenosine diphosphate; NF-κB: Nuclear factor-κB; ICAM-1: Intracellular adhesion molecule-1; LDL: Low density lipoprotein; LOX-1: Oxidized LDL receptor.