Topic Highlight
Copyright ©2010 Baishideng Publishing Group Co.
World J Cardiol. Dec 26, 2010; 2(12): 421-427
Published online Dec 26, 2010. doi: 10.4330/wjc.v2.i12.421
Figure 2
Figure 2 “Redox-window” hypothesis on coronary collateral growth. Existence of a critical “redox-window” is required; either reductive or oxidative stress will corrupt collateral growth and redox-dependent growth-factor signaling. The figure illustrates the principal measure in our system-collateral growth-as a function of the redox state in cells. The summary of this concept is best described as, in situations where there is reductive stress or oxidative stress, collateral growth is corrupted because of either too many neutral or oxidized thiol groups.