Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress

Figure 2 “Redox-window” hypothesis on coronary collateral growth. Existence of a critical “redox-window” is required; either reductive or oxidative stress will corrupt collateral growth and redox-dependent growth-factor signaling. The figure illustrates the principal measure in our system-collateral growth-as a function of the redox state in cells. The summary of this concept is best described as, in situations where there is reductive stress or oxidative stress, collateral growth is corrupted because of either too many neutral or oxidized thiol groups.