Adiponectin and basic fibroblast growth factor predict coronary collateral development in chronic total occlusion

Table 3 Multivariate logistic regression for predictors of good coronary collateral development

Variable	Adjusted OR	95%CI	P value
Serum adiponectin (per 1 μg/mL increase)	1.86	1.25-2.77	0.002a
Serum basic fibroblast growth factor (per 1 pg/mL increase)	0.91	0.48-1.73	0.776
Age (per 1-year increase)	0.98	0.91-1.05	0.531
Diabetes mellitus (yes vs no)	0.46	0.16-1.35	0.156
Hypertension (yes vs no)	0.82	0.28-2.42	0.720
Current smoking (yes vs no)	0.69	0.23-2.08	0.513
CTO target vessel (LAD vs RCA/LCx)	1.74	0.63-4.84	0.286

^aP < 0.05.

Table 3 summarizes the multivariate logistic regression analysis for predictors of good coronary collateral development. After adjustment for the conventional cardiovascular risk factors, serum adiponectin was the only independent predictor of good collateralization (adjusted odds ratio = 1.86, 95% confidence interval: 1.25-2.77; P = 0.002). However, serum basic fibroblast growth factor, age, diabetes mellitus, hypertension, smoking status, and chronic total occlusion target vessel were not independently associated with the development of coronary collateral. These results suggested that adiponectin was a better systemic marker of coronary collateral maturation than circulating basic fibroblast growth factor or conventional clinical risk factors. Outcome: Good coronary collateral development (Rentrop grades 2-3). OR: Odds ratio; CI: Confidence interval; CTO: Chronic total occlusion; LAD: Left anterior descending artery; RCA: Right coronary artery; LCx: Left circumflex artery.