Mitochondrial ultrastructure in cardiac myocytes is associated with the cardiovascular death in patients with heart failure

Table 3 Results of the analysis of associations between the ultrastructural characteristics of mitochondria and the development of adverse cardiovascular events

Parameter		Total area of interfibrillar mitochondria		The ratio of the length of the outer membrane to the length of the inner membrane		Integral indicator
The end point		Value	P value	Value	P value	Value	P value
Death from CVD	No	41 (35; 50)	0.343	29 (20; 33.5)	0.001	1.5 (1; 2.4)	0.024
	Yes	34 (26; 53)		41 (35; 45)		1 (0.7; 1.4)
Hospitalization due to HF	No	40 (34; 48)	0.299	30.5 (24; 37)	0.556	1.3 (0.9; 2.4)	0.619
	Yes	49 (36; 52)		26 (20; 31)		1.8 (1.3; 2.5)
Progression of HF symptoms	No	37 (32; 47)	0.315	28 (19; 36)	0.712	1.4 (0.9; 2.4)	0.573
	Yes	44 (41; 51)		30 (22; 33)		1.7 (0.6; 1.9)
Combined primary end point (MACE)	No	40 (34; 47)	0.795	28 (19; 36)	0.127	1.4 (0.9; 2.4)	0.279
	Yes	44 (31; 51)		33 (26; 41)		1.4 (0.7; 1.9)

CVD: Cardiovascular diseases; HF: Heart failure; MACE: Major adverse cardiovascular events - serious adverse cardiovascular events.