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Publication Name
World Journal of Cardiology
ISSN
1949-8462
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Systematic Reviews
Copyright: ©Author(s) 2026.
World J Cardiol. Jul 26, 2026; 18(7): 120236
Published online Jul 26, 2026. doi: 10.4330/wjc.120236
Figure 1
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Figure 1 Schematic of microRNA biogenesis and gene silencing. Primary microRNA (pri-miRNA) is transcribed by RNA polymerase II from DNA. The microprocessor complex, consisting of Drosha and DiGeorge syndrome critical region 8, cleaves pri-miRNA into a hairpin precursor microRNA (miRNA). The hairpin is exported from the nucleus by exportin-5/RAN-GTP. In the cytoplasm, RNase III endoribonuclease TRBP generate a miRNA duplex. The duplex unwinds, and the mature strand associates with the RNA-induced silencing complex, which directs translational repression or mRNA target cleavage. RISC: RNA-induced silencing complex; miRNA: MicroRNA; Pri-miRNA: Primary microRNA.
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