S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression

doi:10.4330/wjc.v18.i5.120519

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World Journal of Cardiology

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1949-8462

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. May 26, 2026; 18(5): 120519
Published online May 26, 2026. doi: 10.4330/wjc.v18.i5.120519

Table 4 Diagnostic value of sphingosine-1-phosphate receptor 1, interleukin-1β, tumor necrosis factor-α, and their combination in coronary atherosclerotic heart disease

	Area under the curve	SEN (%)	SPE (%)	AC (%)	PPV (%)	NPV (%)
S1PR1	0.779	73.2	75	73.87	73.24	75
IL-1β	0.775	66.2	80	71.17	66.20	80
TNF-α	0.761	74.6	70	72.97	74.65	70
S1PR1 + IL-1β + TNF-α	0.892	84.5	80	82.88	84.51	80

S1PR1: Sphingosine-1-phosphate receptor 1; IL: Interleukin; TNF-α: Tumor necrosis factor-α; SEN: Sensitivity; SPE: Specificity; AC: Diagnostic accuracy; PPV: Positive predictive value; NPV: Negative predictive value.

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Citation: Chu FY, Yao MH, Gu LM, Cai H, Li YN, Chen X, Xu XX. S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression. World J Cardiol 2026; 18(5): 120519
URL: https://www.wjgnet.com/1949-8462/full/v18/i5/120519.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i5.120519

Chu FY, Yao MH, Gu LM, Cai H, Li YN, Chen X, Xu XX. S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression. World J Cardiol 2026; 18(5): 120519 [DOI: 10.4330/wjc.v18.i5.120519]

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