S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression

doi:10.4330/wjc.v18.i5.120519

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World Journal of Cardiology

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1949-8462

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. May 26, 2026; 18(5): 120519
Published online May 26, 2026. doi: 10.4330/wjc.v18.i5.120519

Table 3 Cytokine expressions in the coronary atherosclerotic heart disease group and control group, median (interquartile range)

Cytokine (pg/mL)	CAHD (n = 71)	Control (n = 40)	U value	P value
IL-1β	2.81 (0.60,4.68)	0.77 (0.12,1.04)	638.5	< 0.0001
IL-2	1.91 (0.68, 4.03)	2.71 (1.63, 3.48)	1137.0	0.08
IL-4	2.87 (0.39, 5.24)	7.89 (6.36, 9.71)	428.0	< 0.0001
IL-5	0.86 (0.09, 1.68)	5.28 (4.08, 6.51)	209.0	< 0.0001
IL-6	16.78 (8.56, 24.09)	12.69 (10.59, 15.46)	1125.0	0.07
IL-8	9.79 (5.31, 26.87)	24.32 (16.59, 32.41)	757.0	< 0.0001
IL-10	3.08 (1.8, 4.38)	6.12 (5.09, 7.33)	440.0	< 0.0001
IL-12	0.59 (0.08, 1.46)	2.79 (1.33, 4.02)	581.0	< 0.0001
IL-17	3.8 (1.76, 6.85)	9.89 (8.0, 12.61)	424.5	< 0.0001
TNF-α	4.12 (3.23, 5.26)	2.91 (2.47, 3.65)	678.5	< 0.0001
Interferon-α	0.3 (0.06, 0.89)	2.09 (1.68, 3.10)	383.0	< 0.0001
Interferon-γ	3.16 (1.79, 5.48)	10.23 (9.61, 12.78)	190.0	< 0.0001

CAHD: Coronary atherosclerotic heart disease; IL: Interleukin.

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Citation: Chu FY, Yao MH, Gu LM, Cai H, Li YN, Chen X, Xu XX. S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression. World J Cardiol 2026; 18(5): 120519
URL: https://www.wjgnet.com/1949-8462/full/v18/i5/120519.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i5.120519

Chu FY, Yao MH, Gu LM, Cai H, Li YN, Chen X, Xu XX. S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression. World J Cardiol 2026; 18(5): 120519 [DOI: 10.4330/wjc.v18.i5.120519]

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