S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression

Table 1 General clinical data analysis of coronary atherosclerotic heart disease group and control group, n (%)/mean ± SD/median (interquartile range)

Clinical data	CAHD (n = 71)	Control (n = 40)	χ2/t/U value	P value
Gender (male/female)	49/22	33/7	2.411	0.121
Age (years)	67.31 ± 1.30	57.03 ± 1.40	5.09	< 0.0001
Systolic pressure (mmHg)	134 (123, 147)	128 (123, 136)	1123	0.068
Diastolic pressure (mmHg)	81 (74, 88)	80 (74, 85.75)	1325	0.561
Smoking history	35 (49.30)	9 (22.5)	7.678	0.006
Drinking history	36 (50.70)	12 (30)	4.469	0.035
FBG (mmol/L)	5.75 ± 0.32	4.69 ± 0.17	2.364	0.020
Cholesterol (mmol/L)	5.07 (4.46,5.07)	3.94 (3.16, 4.74)	723.5	< 0.0001
Triglyceride (mmol/L)	1.58 ± 0.09	1.53 ± 0.12	0.34	0.74
High-density lipoprotein-cholesterol (mmol/L)	1.17 (0.98, 1.33)	1.36 (1.2, 1.72)	812.5	0.0002
Low-density lipoprotein-cholesterol (mmol/L)	2.90 ± 0.11	2.34 ± 0.11	3.43	0.0009
Apolipoprotein A1 (g/L)	1.18 ± 0.03	1.31 ± 0.04	2.53	0.013
Apolipoprotein B (g/L)	0.8 (0.66, 0.95)	0.72 (0.63, 0.78)	1037	0.012
Lipoprotein(a) (mg/L)	207 (110, 422)	118 (64.5, 254)	974	0.006
Alanine transaminase (U/L)	23 (15, 32)	18.5 (15, 30.5)	1249	0.29
G-glutamyl transferase (U/L)	26 (18, 39)	21.5 (17, 35.25)	1247	0.29
Uric acid (μmol/L)	345.3 ± 10.11	312.0 ± 15.76	2.114	0.037

Normally distributed continuous data are expressed as mean ± SD and compared using the independent samples t-test. Non-normally distributed continuous data are expressed as median (interquartile range) and compared using the Mann-Whitney U test. Categorical data are expressed as n (%) and compared using the χ² test. CAHD: Coronary atherosclerotic heart disease; FBG: Fasting blood glucose.