Systematic review and meta-analysis of prognostic markers in transthyretin amyloid cardiomyopathy

Table 1 Study characteristics and key features of included studies

Ref.	Country	Study design	Number of ATTR patients	Wild type ATTR patients (in %)	Mean or median age (years)	Male (%)	Mean or median eGFR	Mean or median NT pro BNP	Mean LV ejection fraction (in %)	Mean or median follow-up (in months)
Donnellan et al[5], 2020	United States	Retrospective study	382	71	76	81	45	7558	46.4	35
Martyn et al[17], 2022	United States	Retrospective study	86	65	78	87	45	3152	50	20
Gagliardi et al[18], 2018	Italy	Retrospective study	67	0	71	78	54	3287	51	43
Gillmore et al[19], 2018	United Kingdom	Retrospective study	869	64	77	85	61	3036	NA	32
Nakashima et al[20], 2022	Japan	Retrospective study	176	100	78	85	50	NA	53.4	21
Siepen et al[6], 2018	Germany	Retrospective study	191	100	73.8	92	67.3	3644	45.8	26.2
Gospodinova et al[21], 2020	Bulgaria	Prospective study	78	0	56	50	81.7	NA	61	30
Cappelli et al[22], 2020	Italy	Retrospective study	175	76	78.4	86	66.3	6791	53.9	27
Law et al[23], 2022	United Kingdom	Retrospective study	432	100	77	95	60	2760	48	12
Ogasawara et al[7], 2022	Japan	Retrospective study	68	100	75	90	55	NA	51	22
Hanson et al[24], 2018	United States	Retrospective study	116	100	76	97.4	NA	NA	50	NA
Yunis et al[10], 2019	United States	Prospective study	56	100	74.8	100	NA	NA	50.2	35
Chacko et al[8], 2020	United Kingdom	Prospective study	1240	62	77.5	78.4	NA	NA	48.5	32
Hirakawa et al[9], 2019	Japan	Retrospective study	90	0	56.7	55.6	87.8	NA	61.6	72
Martinez-Naharro et al[11], 2019	United Kingdom	Prospective study	227	59	72	NA	NA	286	56	32
Hein et al[50], 2021	Germany	Prospective study	121	44.6	63.8	75.2	77.5	3616.5	51.8	13.6
Rubin et al[25], 2018	United States	Retrospective study	530	30	58.4	74	89	6503	60.4	18
Bhuiyan et al[26], 2011	United States	Prospective study	29	62	74	93	NA	NA	56	18
Lai et al[27], 2020	Taiwan	Retrospective study	67	NA	65.1	77.6	NA	7720	63.4	31.2
Lane et al[28], 2019	United Kingdom	Retrospective study	1034	69	74	78	66.3	2803	53.3	NA
Sperry et al[29], 2018	United States	Retrospective study	54	69	78	76	54.5	4252	46.2	21.6
Coutinho et al[30], 2013	Portugal	Prospective study	143	0	42	44.8	NA	NA	NA	66
Ruberg et al[51], 2012	United States	Prospective study	29	62	74	93	NA	4643	59	15.5
Vong et al[31], 2021	Multiple (13 countries)	RCT	441	76	75	90	NA	461.1	47.8	30
Oghina et al[32], 2021	France	Retrospective study	454	70.5	77	82.4	59.2	1980	50.1	14.2
Oike et al[33], 2021	Japan	Retrospective study	113	100	79.8	85	47.6	NA	51	22.3
Hutt et al[34], 2017	United Kingdom	Prospective study	602	62.6	75	86	57	2765	49	29.6
Dalia et al[35], 2021	United States	Retrospective study	33	100	82	79	NA	NA	50	12
Donnellan et al[36], 2020	United States	Retrospective study	369	70.7	75.5	82	44	8152	46	28
Kharoubi et al[37], 2021	France	Prospective study	62	100	78.6	93.5	59.8	4528	46.8	NA
Ochi et al[38], 2020	Japan	Retrospective study	47	100	80.3	87.2	49.9	NA	49.6	28.32
Kristen et al[39], 2014	Germany	Prospective study	70	NA	67.4	75.5	71.1	1950	NA	31.3
Grogan et al[40], 2016	United States	Retrospective study	360	100	75.5	91	NA	2838	51	31.2
Fumagalli et al[41], 2021	United States	Retrospective study	160	87	80	90.6	NA	3275	54	21
Siddiqi et al[42], 2022	United States	Retrospective study	104	100	75.8	97	60.25	NA	49	39
Kristen et al[43], 2017	United States	Retrospective study	1617	10.2	43.9	54.5	104.5	NA	NA	14.4
Connors et al[44], 2016	United States	Prospective study	121	100	75.6	98	NA	NA	48	NA
Cheng et al[45], 2020	United States	Retrospective study	309	66	73.2	84.1	60.1	NA	45.1	23
Law et al[46], 2020	United Kingdom	Retrospective study	945	77.1	78	82.5	57.5	2836	47	24
Miller et al[47], 2021	Canada	Retrospective study	43	NA	79.3	83.7	NA	NA	49	14
Bandera et al[48], 2022	United Kingdom	Retrospective study	906	62.3	75.3	85.2	58.3	3205	47	35
Yamada et al[49], 2020	Japan	Retrospective study	129	100	78.5	85	50.3	NA	53.2	15

ATTR: Transthyretin amyloidosis; eGFR: Glomerular filtration rate; LV: Left ventricle; BNP: Brain natriuretic peptide; NT pro BNP: N-terminal pro BNP; NA: Not available.