Daming capsule combined with SGLT2i confers protection against diabetes with myocardial ischemia/reperfusion injury induced ferroptosis via AMPK

Figure 2 Diabetes mellitus with ischemia-reperfusion mice exhibited severe glucose and lipid metabolism disorders. A: Statistical analysis of fasting blood glucose; B: The content of total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein in serum; C: The activity of lactate dehydrogenase in serum; D: Representative images of BODIPY 493/503 staining of myocardial tissue and statistical graph. Above results are presented as the mean ± SD. The comparison between more groups was conducted by one-way analysis of variance. ^aP < 0.05 vs the wild type group; ^bP < 0.05 vs the diabetes mellitus group. WT: Wild type; I/R: Ischemia-reperfusion; DM: Diabetes mellitus; LDH-c: Lactate dehydrogenase cholesterol; LDL-c: Low-density lipoprotein cholesterol; TC: Total cholesterol; TG: Triglyceride.