Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis

doi:10.4330/wjc.v18.i4.115712

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World Journal of Cardiology

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1949-8462

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Apr 26, 2026; 18(4): 115712
Published online Apr 26, 2026. doi: 10.4330/wjc.v18.i4.115712

Table 3 Characteristics of interventions and comparators

Ref.	Characteristics of compared arms
Ref.	Component of compared arms	Dosage, description	Duration (month)	Assessment of adherence
Preiss et al[22], 2014	Metformin	850 mg twice daily; initial dose 850 mg once daily for one week	18.0	Tablet counts of numbered bottles
Preiss et al[22], 2014	Placebo	Matching placebo	18.0	Tablet counts of numbered bottles
Lexis et al[23], 2015	Metformin plus standard care	Metformin 500 mg twice daily	4.0	NR
	Metformin plus standard care	Standard care		NR
	Standard care	Standard care		N/A
Hartman et al[24], 2017	Metformin plus standard care	Metformin 500 mg twice daily	4.0	NR
	Metformin plus standard care	Standard care		NR
	Standard care	Standard care		N/A
Mohan et al[25], 2019	Metformin	Metformin 1000 mg twice daily; initial dosage 500 mg twice daily for two weeks	12.0	NR
Mohan et al[25], 2019	Placebo	Matching placebo	12.0	NR

NR: Non-reported; N/A: Not applicable.

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Citation: Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712
URL: https://www.wjgnet.com/1949-8462/full/v18/i4/115712.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i4.115712

Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712 [DOI: 10.4330/wjc.v18.i4.115712]

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