Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis

doi:10.4330/wjc.v18.i4.115712

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Apr 26, 2026; 18(4): 115712
Published online Apr 26, 2026. doi: 10.4330/wjc.v18.i4.115712

Table 1 Characteristics of eligible studies

Ref.	Country	Study duration (month)	Follow-up duration (month)	Drop-out rate, n (%)
Preiss et al[22], 2014	Scotland, United Kingdom	18	0	13 (7.5)
Lexis et al[23], 2015	Netherlands	4	0	0 (0.0)
Hartman et al[24], 2017	Netherlands	28	24	0 (0.0)
Mohan et al[25], 2019	Scotland, United Kingdom	12	0	5 (7.4)

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Citation: Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712
URL: https://www.wjgnet.com/1949-8462/full/v18/i4/115712.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i4.115712

Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712 [DOI: 10.4330/wjc.v18.i4.115712]

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